Gene description for APP
Gene name amyloid beta precursor protein
Gene symbol APP
Other names/aliases AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
alpha-sAPP
preA4
Species Homo sapiens
 Experiment description of studies that identified APP in Prostate cancer cells

1
Experiment ID136
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method
Mass spectrometry [QTOF]   Supporting data   MSS   
PubMed ID 22723089   
OrganismHomo sapiens
Experiment descriptionExosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes.
AuthorsHosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year2012
SampleProstate cancer cells
Sample namePC3 - Rep 2
Isolation/purification methodsSucrose density gradient
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [QTOF]
EV-TRACK EV120018: EV-METRIC:38%

2
Experiment ID137
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method
Mass spectrometry [QTOF]   Supporting data   MSS   
PubMed ID 22723089   
OrganismHomo sapiens
Experiment descriptionExosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes.
AuthorsHosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year2012
SampleProstate cancer cells
Sample namePC3 - Rep 3
Isolation/purification methodsSucrose density gradient
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [QTOF]
EV-TRACK EV120018: EV-METRIC:38%

3
Experiment ID146
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method
Mass spectrometry [QTOF]   Supporting data   MSS   
PubMed ID 22723089   
OrganismHomo sapiens
Experiment descriptionExosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes.
AuthorsHosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year2012
SampleProstate cancer cells
Sample nameRWPE - Rep 2
Isolation/purification methodsSucrose density gradient
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [QTOF]
EV-TRACK EV120018: EV-METRIC:38%

4
Experiment ID634
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry [LTQ]
PubMed ID 27894104   
OrganismHomo sapiens
Experiment descriptionProteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.
AuthorsHurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr.
Journal name Oncotarget
Publication year2016
SampleProstate cancer cells
Sample namePC-3
Isolation/purification methodsDifferential centrifugation
Polymer-based precipitation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry [LTQ]
EV-TRACK -

5
Experiment ID963
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 25844599   
OrganismHomo sapiens
Experiment descriptionMolecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
AuthorsKharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, UlléA, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year2015
SampleProstate cancer cells
Sample nameDU145 Tax-Sen
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density1.12-1.19 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK EV150027: EV-METRIC:11%, 56%

6
Experiment ID964
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 25844599   
OrganismHomo sapiens
Experiment descriptionMolecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
AuthorsKharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, UlléA, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year2015
SampleProstate cancer cells
Sample nameDU145 Tax-Res
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density1.13-1.18 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK EV150027: EV-METRIC:11%, 56%

7
Experiment ID1260
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 24371517   
OrganismHomo sapiens
Experiment descriptionExosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients.
AuthorsBijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR.
Journal name J Extracell Vesicles.
Publication year2013
SampleProstate cancer cells
Sample nameLNCaP
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK EV130168: EV-METRIC:11%, 11%

8
Experiment ID1261
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 24371517   
OrganismHomo sapiens
Experiment descriptionExosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients.
AuthorsBijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR.
Journal name J Extracell Vesicles.
Publication year2013
SampleProstate cancer cells
Sample namePC3
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK EV130168: EV-METRIC:11%, 11%

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